Orthostatic hypertension

Orthostatic hypertension or postural hypertension is a medical condition consisting of a sudden increase in blood pressure when a person stands up.[1] Orthostatic hypertension is diagnosed by a rise in systolic blood pressure of 20 mmHg or more when standing. Orthostatic diastolic hypertension is a condition in which the diastolic raises to 98 mmHg or over in response to standing;[2][3] however, this definition currently lacks clear medical consensus, and is thus subject to change. Orthostatic hypertension involving the systolic is known as systolic orthostatic hypertension.

Orthostatic hypertension if affecting the individuals ability to remain upright, is viewed as a form of orthostatic intolerance. The body's inability to regulate the blood pressure can be a type of dysautonomia.

Baroreflex and autonomic pathways normally ensure that blood pressure is maintained despite various stimuli including posteral change. The precise mechanism of orthostatic hypertension thou remains unclear but it is thought that alpha-adrenergic activity may be the predominant pathophysiologic mechanism of orthostatic hypertension in elderly hypertensive patients.[4] Other mechanisms are proposed for other different groups of individuals with this disorder.[1]

A prevalence of 1.1% was found in a large population study.[5] The risk of orthostatic hypertension has been found to increase with age, with it being found in 16.3% of older, hypertensive patients.[6]

Dr. David H.P. Streeten is the discoverer of orthostatic hypertension.[7]

Contents

Symptoms

Connections to other disorders

Treatments

There is not any official recommended treatments currently for orthostatic hypertension as the condition is still little known and can be due to different causes, hence treatment for those with this disorder is still trial and error experimental treatment. Some treatments which have been successfully used for this condition are medications doxazosin,[13] carvedilol,[14] captopril, and propranolol hydrochloride. Treatment of coexisting conditions e.g. hypovolemia. Some specialists in severe cases give saline IVs for the hypovolemia which then if that is the cause, brings the orthostatic hypertension down to a safe level. Pressure garments over the pelvis and the lower extremeties may be used as part of treatment, due to the blood pooling issue happening in many with the disorder. [15]

Risks

References

  1. ^ a b c d Fessel, J.; Robertson, D. (2006). "Orthostatic hypertension: When pressor reflexes overcompensate". Nature Clinical Practice Nephrology 2 (8): 424–431. doi:10.1038/ncpneph0228. PMID 16932477.  edit
  2. ^ Bell, David S. (May 2000). "Orthostatic Intolerance (OI) Test Results". Lyndonville News 2 (3). http://www.oiresource.com/tresults.htm. 
  3. ^ Streeten, D.H.P. (1987). Orthostatic Disorders of the Circulation. New York: Plenum Medical. p. 116. 
  4. ^ a b Kario, K.; Eguchi, K.; Hoshide, S.; Hoshide, Y.; Umeda, Y.; Mitsuhashi, T.; Shimada, K. (2002). "U-curve relationship between orthostatic blood pressure change and silent cerebrovascular disease in elderly hypertensives: Orthostatic hypertension as a new cardiovascular risk factor". Journal of the American College of Cardiology 40 (1): 133–141. PMID 12103267.  edit
  5. ^ Wu, J. S.; Yang, Y. C.; Lu, F. H.; Wu, C. H.; Chang, C. J. (2008). "Population-Based Study on the Prevalence and Correlates of Orthostatic Hypotension/Hypertension and Orthostatic Dizziness". Hypertension Research 31 (5): 897–904. doi:10.1291/hypres.31.897. PMID 18712045.  edit
  6. ^ a b Fan, X. H.; Sun, K.; Zhou, X. L.; Zhang, H. M.; Wu, H. Y.; Hui, R. T. (2011). "Association of orthostatic hypertension and hypotension with target organ damage in middle and old-aged hypertensive patients". Zhonghua yi xue za zhi 91 (4): 220–224. PMID 21418863.  edit
  7. ^ Moses, A. M.; Weinstock, R. S. (2001). "In memoriam: David H. P. Streeten". The Journal of clinical endocrinology and metabolism 86 (2): 471–472. PMID 11157991.  edit
  8. ^ Streeten, D. H.; Auchincloss Jr, J. H.; Anderson Jr, G. H.; Richardson, R. L.; Thomas, F. D.; Miller, J. W. (1985). "Orthostatic hypertension. Pathogenetic studies". Hypertension 7 (2): 196–203. PMID 3980066.  edit
  9. ^ Streeten, D. H.; Anderson Jr, G. H.; Richardson, R.; Thomas, F. D. (1988). "Abnormal orthostatic changes in blood pressure and heart rate in subjects with intact sympathetic nervous function: Evidence for excessive venous pooling". The Journal of laboratory and clinical medicine 111 (3): 326–335. PMID 3343547.  edit
  10. ^ Benowitz, N. L.; Zevin, S.; Carlsen, S.; Wright, J.; Schambelan, M.; Cheitlin, M. (1996). "Orthostatic hypertension due to vascular adrenergic hypersensitivity". Hypertension 28 (1): 42–46. PMID 8675262.  edit
  11. ^ Tsukamoto, Y.; Komuro, Y.; Akutsu, F.; Fujii, K.; Marumo, F.; Kusano, S.; Kikawada, R. (1988). "Orthostatic hypertension due to coexistence of renal fibromuscular dysplasia and nephroptosis". Japanese circulation journal 52 (12): 1408–1414. PMID 2977192.  edit
  12. ^ Takada, Y.; Shimizu, H.; Kazatani, Y.; Azechi, H.; Hiwada, K.; Kokubu, T. (1984). "Orthostatic hypertension with nephroptosis and aortitis disease". Archives of internal medicine 144 (1): 152–154. PMID 6362595.  edit
  13. ^ Hoshide, S.; Parati, G.; Matsui, Y.; Shibazaki, S.; Eguchi, K.; Kario, K. (2011). "Orthostatic hypertension: Home blood pressure monitoring for detection and assessment of treatment with doxazosin". Hypertension Research. doi:10.1038/hr.2011.156. PMID 21918522.  edit
  14. ^ Moriguchi, A.; Nakagami, H.; Kotani, N.; Higaki, J.; Ogihara, T. (2000). "Contribution of cardiovascular hypersensitivity to orthostatic hypertension and the extreme dipper phenomenon". Hypertension research : official journal of the Japanese Society of Hypertension 23 (2): 119–123. PMID 10770258.  edit
  15. ^ >Streeten, D. H.; Auchincloss Jr, J. H.; Anderson Jr, G. H.; Richardson, R. L.; Thomas, F. D.; Miller, J. W. (1985). "Orthostatic hypertension. Pathogenetic studies". Hypertension 7 (2): 196–203. PMID 3980066.  edit
  16. ^ Kario, K. (2009). "Orthostatic hypertension: A measure of blood pressure variation for predicting cardiovascular risk". Circulation journal : official journal of the Japanese Circulation Society 73 (6): 1002–1007. PMID 19430163.  edit
  17. ^ Yatsuya, H.; Folsom, A. R.; Alonso, A.; Gottesman, R. F.; Rose, K. M.; Aric Study, I. (2011). "Postural changes in blood pressure and incidence of ischemic stroke subtypes: The ARIC study". Hypertension 57 (2): 167–173. doi:10.1161/HYPERTENSIONAHA.110.161844. PMC 3214760. PMID 21199999. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3214760.  edit